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Information for Prescribing Naltrexone | Statistics | The Cure for Alcoholism | Additional Information


Information for Prescribing Naltrexone

Dear Doctor

The patient carrying this letter to you would like your support in a highly effective treatment for alcoholism: it is called TSM and has a 78% cure rate. It requires a prescription for naltrexone.

The FDA approved naltrexone in 1995 for use in the treatment of alcohol dependence. Important new evidence has been obtained since then about how to use naltrexone much more effectively.

First, a dual double-blind clinical trial1 showed that the usual protocol of having patients take naltrexone while abstinent is not effective. To be effective, naltrexone and alcohol must be in the system concurrently. Therefore, naltrexone must always be taken one hour before consuming alcohol. The resulting mechanism of extinction then gradually reduces craving and drinking over several months, and produces a natural detoxification - thus avoiding the distress and complications of rapid withdrawal. The result has beenreplicated and is consistent with findings from nearly all of the 82 clinical trials conducted to date.2

Second, it is now clear that naltrexone can be prescribed by doctors without an accompanying program of intensive counselling. Naltrexone was originally approved by the FDA as an adjunct within comprehensive programs of alcoholism treatment. The results of Project Combine (JAMA. 2006), the largest clinical trial in the alcohol field, showed, however, that naltrexone was effective without the need for intensive counselling where patients are treated in general medical settings.3

The bottom line is that TSM has proven to be far more successful than any other treatment for alcoholism on the market to date, and your patient is keen to try this method.

Detailed information can be found in Dr. Roy Eskapa’s book, The Cure for Alcoholism4 containing instructions to physicians, can be downloaded on the internet at: - Click on ‘About the Book’ Chapter 17 – ‘For Medical Professionals’

Additional documentation may be requested by emailing:

David Sinclair, Ph.D.
National Institute for Health and Welfare (THL)
Helsinki, Finland

Stephen Cox, MD
Head of the National Anxiety Association
University of Kentucky
Lexington, KY

1 Heinälä, P., Alho, H., Kiianmaa, K., Lönnqvist, J., Kuoppasalmi, K., and Sinclair, J.D. (2001).
Targeted use of Naltrexone without prior detoxification in the treatment of alcohol dependence: A factorial double-blind placebo-controlled trial. Journal of Clinical Psychopharmacology, 21(3): 287-292.

2 Sinclair, J. D. (2001) Evidence about the use of Naltrexone and for different ways of using it in the treatment of alcoholism. Alcohol and Alcoholism 36: 2-10; Sinclair, D. and F.Fantozzi (2004) Relapse prevention with extinction . In: Relapse prevention in the treatment of alcohol dependence. Personalit Dipendenze 10 (fasc.II): 219-243.

3 Anton RF, O’Malley, SS Ciraulo DC, Cisler RA. Couper D, Donovan DM, Gastfriend DR, Hosking JD, Johnson BA, LoCastro JS, Longabaugh R, Mason BJ, Mattson ME, Miller WR, Pettinati HM, Randall CL, Swift R, Weiss RD, Williams LD, Zweben AZ, for the COMBINE Study Research Group (2006) Combined pharmacotherapies and behavioral interventions for alcohol dependence: The COMBINE Study: A Randomized Controlled Trial JAMA. 2006;295:2003-2017.

4 Eskapa, R (2008) The Cure for Alcoholism. Dallas: Ben Bella Books, 320 pages – Several chapters may be downloaded at - click on ‘About the Book’


Global Statistics

The World Health Organization (WHO) estimates that there are about 2 billion people worldwide who consume alcoholic beverages and 76.3 million with diagnosable alcohol use disorders. From a public health perspective, the global burden related to alcohol consumption, both in terms of morbidity and mortality, is considerable in most parts of the world. Alcohol consumption has health and social consequences via intoxication (drunkenness), alcohol dependence, and other biochemical effects of alcohol. In addition to chronic diseases that may affect drinkers after many years of heavy use, alcohol contributes to traumatic outcomes that kill or disable at a relatively young age, resulting in the loss of many years of life due to death or disability.

Overall there is a causal relationship between alcohol consumption and more than 60 types of disease and injury. Alcohol is estimated to cause about 20–30% of esophageal cancer, liver cancer, cirrhosis of the liver, homicide, epileptic seizures, and motor vehicle accidents worldwide (WHO, 2002).

Alcohol causes 1.8 million deaths each year. Unintentional injuries, including motor vehicle accidents, account for about one third of deaths. Alcohol consumption is the leading risk factor for disease burden in low mortality developing countries and the third largest risk factor in developed countries.

The British Medical Association (BMA) estimates that one in twenty-five adults in the United Kingdom is “alcohol dependent.” The Center for Public Health at John Moores University in Liverpool in England found that 18.2 percent of British adults binge drink more than double the daily recommended limit at least once a week. The UK office for population censuses and surveys claims that 7.5 percent of men and 2.1 percent of women are “dependent on alcohol.”

In European Union countries, more than 20 million people drink to excess and alcohol addiction accounts for nearly 10 percent of “ill-health and deaths.” The 2006 European School Survey Project on Alcohol and Other Drugs discovered that the European Union has “the highest proportion of drinkers and the highest level of alcohol consumption” in the world.

In Europe, alcohol consumption was responsible for over 55,000 deaths among young people aged 15–29 years in 1999 (Rehm & Eschmann, 2002).


American Statistics

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) wrote that “Approximately 1 million Americans seek alcoholism treatment each year, many more than once.” According to NIAAA, however, there are 17 to 18 million Americans with serious drinking problems with 8 million fitting the diagnosis for full-blown alcoholism. A National Household Survey puts the U.S. total for underage binge drinkers – more than five units in one sitting – at a staggering 46 million.

In America, the NIAAA also found that alcoholism is the costliest disease, draining U.S. society of $187 billion annually; that is almost half the entire Pentagon budget for 2003.

According to the American Medical Association, alcoholism accounts for 3.5 percent of all annual deaths – 105,000 – in the United States.

The Sinclair Method has successfully treated alcohol addiction in Finland, where excessive alcohol use is a major national problem, as well as in Israel, Russia, Australia, The Netherlands, Italy, Spain, Venezuela and Estonia.

The method is successful with more than 78% of alcoholics. At a center in Florida offering The Sinclair Method, the success rates since 2002 have been more than 85%.

During the treatment program when shown on a graph a pattern emerges. It is always a classical extinction curve: drinking and craving become progressively lower with each week of treatment.


The Cure for Alcoholism

The Cure for Alcoholism by Roy Eskapa, PhD

Finally, there is a cure for alcoholism. This is the first step.

Featuring new and updated information and studies, including an introduction by actress Claudia Christian, the second edition of The Cure for Alcoholism delivers exactly what millions of alcoholics and families of alcoholics have been hoping for: a painless, dignified, and medically proven cure for their addiction. Backed by 82 clinical trials and research that extends back to 1964. The Sinclair Method deploys an opiate-blocking medication in a very specific way — in combination with ongoing drinking — to extinguish the addictive “software” in the brain. The de-addiction process rolls back the addictive mechanism in the brain to its original pre-addicted state — before the first drink was consumed, making this program an actual cure for alcoholism.

Drs. Roy Eskapa and David Sinclair of The Sinclair Method have put together a sound scientific book that proves that with this particular method, alcoholism can be cured in more than 78 percent of patients. What’s more, the treatment avoids the dangerous withdrawal symptoms, allowing patients to detox gradually and safely while they are still drinking. This removes the need for expensive and unpleasant inpatient rehabilitation programs. Actual drinking levels and cravings automatically decrease until control over alcohol is restored. The bottom line is that patients can control their drinking or stop altogether with the simple yet powerful process outlined in The Cure for Alcoholism.

Including a new introduction by actress Claudia Christian about The Sinclair Method’s impact on her life, updated trial information, and a letter explaining the treatment that can be given to doctors by patients, The Cure for Alcoholism is a revolutionary book for anyone who wants to gain control over drinking.


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